The purpose of this review was to examine studies providing evidence of principles of motor learning (PML) and its effectiveness in the treatment of childhood apraxia of speech (CAS). An electronic search was conducted with databases accessed from the Rockhurst University library. Inclusion criteria required studies to have been published within the last ten years (2004-2014), to have used children with a diagnosis of CAS and to have focused on the role of at least one PML in CAS treatment. The five studies that met these criteria specifically examined the use of high frequency practice, distributed and massed practice, varied practice, frequency of feedback and blocked and random practice. A quality analysis rated the studies as moderate quality studies, classifying them as a level two in the levels of evidence. Seventeen children were involved in some type of motor based approach that encompassed one or more PML. Four out of the five studies showed significant gains in performance, one reporting mixed results. The evidence gathered from these five studies cannot be considered sufficient enough to support the hypothesis that using specific PML parameters are effective in treating CAS. The small sample size is a considerable limitation of this review as well as the lack of research, not only in the area of PML but etiology, diagnosis and treatment of CAS.